GIP and GLP-1 glucoregulatory actions in type 2 diabetes Insulin responses to both GIP and GLP-1 infused to mimic normal postprandial concentrations during a hyperglycaemic clamp were markedly diminished in people with long-standing type 2 diabetes, and were improved, but not normalised, after 4 weeks of insulin therapy [61]
Anti-Inflammatory Effects Chronic inflammation is exhausting
Wegovy 2.4 mg FlexTouch is used for chronic weight management in adults who are overweight or have obesity, in conjunction with a reduced-calorie diet and increased physical activity
Nonscale victories: Pants button differently
1mg dose: 8.7% average weight loss 4mg dose: 15.2% average weight loss 8mg dose: 21.1% average weight loss 12mg dose: 24.2% average weight loss Placebo: 2.1% average weight loss For practical context, a person starting at 220 pounds would lose approximately 53 pounds at the highest dose over 48 weeks
Metsera is proving there is still room for the new guy in the GLP-1 world